Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI

Table 2

Summary of KC activation and reaction.

Donor	Drug tested	ROI formation	Cell activity	IL-6	TNF-a	IL-10	PGF-2
A	APAP	↑	—	↑	—	—	↓
	DIC	—	—	↓↓	↓	—	↓↓
B	APAP	↑	↑	—	↑	—	↓
	DIC	↑↑	↑	↑	↑	—	↓↓
C	APAP	↓	↑	—	—	—	↑
	DIC	↓↓	↑↑	—	↑	↑	↓↓

↑: slight increase, ↑↑: increase, ↓: slight decrease, ↓↓: decrease, and —: no change.
All data were compared to the control.