Clinical Study
Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4
Table 1
Characteristics, chemistry values, and clinical symptoms in 48 patients with STEC-HUS mediated by Escherichia coli O104:H4.
| | Variable | Admission | Day 3 |
| | Demographics | | | Number of patients (, %) | 48 (100) | | Age (years, median (IQR)) | 45 (27–57) | | Female sex (, %) | 35 (72.9) | | Positive test for Shiga toxin or EHEC (, %) | 45 (93.8) | | Onset of diarrhea (median (IQR)) | 2 (1–4) | | Medical history (, %) | | | Arterial hypertension | 11 (22.9) | | Diabetes mellitus | 2 (4.2) | | Coronary heart disease | 2 (4.2) | | Chronic kidney disease | 0 (0) | | Laboratory data (median (IQR)) | | | Creatinine (μmol/L) | 202 (120–335) | 264.5 (184.8–344) | | eGFR (mL/min/1.73 m2) | 26 (15–51.5) | 20 (13–33) | | LDH (U/L) | 1018 (749–1429) | 886 (651–1142.3) | | Platelets (/nL) | 46 (32–64) | 52 (23–72) | | Hemoglobin (g/dL) | 11.2 (9.8–12.4) | 9.2 (8.3–10.4) | | Angiopoietin-1 [ng/mL] | 1.5 (0.7–2.1) | 1.36 (0.95–2.29) | | Angiopoietin-2 [ng/mL] | 2.4 (2–3.2) | 2.6 (1.8–3.28) | | Clinical data (, %) | | | Complicated course | 32 (66.7) | | Need of RRT | 32 (66.7) | | Seizures | 10 (20.8) | | Need of mechanical ventilation | 9 (18.8) |
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