Mediators of Inflammation / 2015 / Article / Tab 2 / Review Article
Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest Table 2 Cytokines with prognostic implications.
Cytokines involved Primary myelofibrosis Essential thrombocythemia Polycythemia vera Low survival High DIPSS categories ↑ IL8 and/or sIL2Ra [13 ] ↑ IL10 [13 ] ↑ IL12 [13 ] ↑ IL15 [13 ] ND MIP-1β [13 ] Progression to myelofibrosis — ↑ IL2 [16 ] ↑ IL2ra [16 ] ↑ IL2 [16 ] ↑ IL2ra [16 ] Leukemic transformation ↑ IL8 and/or sIL2Ra [13 ] ↑ IL2 and sIL2Ra [6 , 8 , 16 ] ↑ IL6 [6 ] ND ND Vascular events ND ND ↑ IL12 [15 ] ↑ GM-CSF [15 ]
This table represents prognostic values of cytokines described in PV, ET, and PMF. ↑ means increase in cytokine level; ND means not described to our knowledge.