Levo-Tetrahydropalmatine Attenuates Bone Cancer Pain by Inhibiting Microglial Cells Activation

Figure 2

Long-term inhibitory effects of repetitive administrations of L-THP on TCI-induced pain behaviors. L-THP 60 mg/kg was administered intragastrically from postoperative day 7 and then once every other day for repetitive 7 days till postoperative day 19. Thermal hyperalgesia (a) and mechanical allodynia (b) are shown in the hind paw ipsilateral to TCI. Administration is indicated by arrows. Eight rats were tested in each group. and indicate significant differences compared with sham group. and indicate significant differences compared with TCI group.

(a)

(b)