|
| IL-10 family member | Lung | Kidney | Intestine | Heart | Liver |
|
| IL-10 | IL-10 KO (mouse): inflammation ↑ [47]
BLEO-induced pulmonary fibrosis (mouse) + IL-10: TGF- ↓ [48]
IPF (human): serum IL-10 ↑ [49]
ILD (human): BAL IL-10 ↑ [50–52] | UUO IL-10 KO (mouse): fibrosis ↑ and inflammatory chemokines ↑ [53]
UUO (mouse) + IL-10 in hyaluronic acid hydrogels: fibrosis ↓ [54, 55] | IBD (human): serum, mucosa IL-10 ↑/→ [56–58]
IL-10 loss of function mutation: IBD ↑ [59]
IBD + IL-10: dose dependent improvement of disease activity [60, 61] | Isoproterenol-induced fibrosis IL-10 KO (mouse): fibrosis ↑ [62]
Isoproterenol-induced fibrosis (mouse) + IL-10: fibrosis ↓ [63]
Myocarditis (dog): serum IL-10 ↓ and fibrosis ↑ [64]
Autoimmune myocarditis + IL-10 (mouse): fibrosis ↓ [65] | Acute, chronic liver injury (mouse): IL-10 ↑ [66]
IL-10 KO + CCl4: fibrosis ↑ [67, 68]
Thioacetamide-induced liver fibrosis + IL-10 gene therapy (mouse): fibrosis ↓ [69] |
|
| IL-19 | — | CKD (human): urinary IL-19 ↑ [70]
Nephrotoxic agents (epithelial cells): IL-19 ↑ [70]
Renal tubular epithelial cells + IL-19: apoptosis ↑ [71] | IBD (human): serum IL-19 ↓ [72]
IL-19 KO (mouse): fibrosis ↑ [73] | — | — |
|
| IL-20 | — | CKD (human): urinary IL-20 ↑ [74]
Nephrotoxic agents (renal epithelial cells): IL-20 ↑ [75]
Renal tubular epithelial cells + IL-20: apoptosis ↑ [75] | Active IBD (human): serum, mucosa IL-20 ↑ [76] | — | Liver fibrosis (human): IL-20 ↑ [77]
CCl4-induced liver fibrosis (mouse): IL-20 ↑ [77]
CCl4-induced liver fibrosis + IL-20 neutralizing sb/IL-20 KO: fibrosis ↓ [77] |
|
| IL-22 | BLEO-induced pulmonary fibrosis (mouse) + IL-22: fibrosis ↓ [78]
BLEO-induced pulmonary fibrosis (mouse) + IL-22 neutralizing ab: fibrosis ↑ [78]
HP (mouse) + IL22: fibrosis ↓ [79]
HP (mouse) + IL22 neutralizing ab: fibrosis ↑ [79] | I/R (mouse): serum IL-22 ↑ [80]
I/R (mouse) + IL-22: tubulointerstitial injury ↓ [80] | IBD (human) serum, mucosa IL-22 ↑ [81]
DSS colitis (mouse) + IL-22 neutralizing ab: inflammation ↑ [82]
DSS colitis IL-22 KO (mouse): inflammation ↑ [83] | Dilated cardiomyopathy, cardiac fibrosis (mouse): IL-22 ↑ [84]
Cardiac fibrosis (mouse) + IL-22 neutralizing ab: fibrosis ↓ [84] | Ethanol-induced liver fibrosis (mouse) + IL-22: liver injury ↓, antiapoptotic, antioxidant genes ↑ [85, 86]
High fat diet (mouse) + IL-22: liver TNF- ↓ [87]
CCl4-induced liver fibrosis (mouse) + IL-22: fibrosis ↓ [88]
Concanavalin-induced hepatitis + IL-22 neutralizing ab: liver injury ↑ [89]
HCV and alcoholic liver fibrosis (human): serum, liver IL-22 ↑ [90] |
|
| IL-24 | — | — | Active IBD (human): serum IL-24 ↑ [91]
HT-29 + IL-24: membrane-bound mucin-1, mucin-3, and mucin-4 ↑ [92] | — | — |
|
| IL-26 | — | — | IBD (human): serum IL-26 ↑ [93] | — | — |
|
| IL-28 | — | — | — | — | — |
|
| IL-29 | — | — | — | — | — |
|
