Therapeutic Effect of Chenodeoxycholic Acid in an Experimental Rabbit Model of Osteoarthritis

<div>(a) Representative hematoxylin-eosin (HE) stained sections of synovial membrane are shown. Magnification 100x. (b) Histological sores for synovial membrane in the five groups of experimental rabbits. Results are presented as individual data points and the median for each group is indicated by a horizontal bar. <sup>###</sup><svg height="8.9689pt" id="M10" style="vertical-align:-0.1625795pt" version="1.1" viewbox="0 -8.80632 51.6882 8.9689" width="51.6882pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="617" vert-adv-y="617"></glyph.data></g><g transform="matrix(.0135,0,0,-0.0135,12.15,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path><glyph.data 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Similar results were observed in two separated experiments.</div>

Mediators of Inflammation

fig3

Figure 3

Figure 3: Therapeutic Effect of Chenodeoxycholic Acid in an Experimental Rabbit Model of Osteoarthritis 