Erythropoietin Exacerbates Inflammation and Increases the Mortality of Histoplasma capsulatum-Infected Mice

Figure 1

EPO pretreatment decreases the survival of Hc-infected mice. (a) Schematic representation of EPO treatment. In all experiments mice were treated with 45 U EPO three times per week, one week before Hc infection with (b) lethal (1 × 10⁶ yeasts/100 μL/mouse) or (c) sublethal (5 × 10⁵ yeasts/100 μL/mouse) (i.t.). Survival was followed up to 15 or 35 days, as indicated (). The log-rank test was used and differences were considered significant when .

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