Role of IL-38 and Its Related Cytokines in Inflammation

Table 1

IL-1 family members [10, 11].

Cytokine	Family name	Receptor	Coreceptor	Property
IL-1	IL-1F1	IL-1RI	IL-1RAcp	Proinflammatory
IL-1	IL-1F2	IL-1RI	IL-1RAcp	Proinflammatory
IL-1Ra	IL-1F3	IL-1RI	NA	Antagonist for IL-1, IL-1
IL-18	IL-1F4	IL-18Rα	IL-18R	Proinflammatory
IL-36Ra	IL-1F5	IL-36R	NA	Antagonist for IL-36, IL-36, and IL-36
IL-36	IL-1F6	IL-36R	IL-1RAcp	Proinflammatory
IL-37	IL-1F7	IL-18R?	Unknown	Anti-inflammatory, transcription regulating factor [12]
IL-36	IL-1F8	IL-36R	IL-1RAcp	Proinflammatory
IL-36	IL-1F9	IL-36R	IL-1RAcp	Proinflammatory
IL-38	IL-1F10	IL-36R	Unknown	Antagonist for IL-36, IL-36, and IL-36
IL-33	IL-1F11	ST2	IL-1RAcp	Proinflammatory, transcription regulating factor [13]

NA: not applicable; ?: requires confirmation.