The Role of Poly(ADP-ribose) Polymerase-1 in Rheumatoid Arthritis

Table 1

Effect of PARP inhibition/deletion in experimental arthritis.

Treatment/genetic approach	Arthritis model	Major findings	Reference
Nicotinamide	Potassium peroxochromate-induced arthritis	Reduced arthritis severity.; Reduction of phagocytic generation of reactive oxygen species.	[30]
Nicotinic acid amide	Collagen-induced arthritis	Reduced arthritis severity.; Synergistic effect with thalidomide.	[31]
INH2BP	Collagen-induced arthritis	Reduced arthritis severity and incidence.; Reduced neutrophil infiltration.; Reduced O2 and N2 derived free radical production.	[33]
PJ34	Collagen-induced arthritis	Reduced arthritis severity and incidence.; Reduced neutrophil infiltration.; Reduced O2 and N2 derived free radical production.	[34]
AIQ	Collagen-induced arthritis	Reduced arthritis severity and incidence.; Reduced inflammatory response.; Reduced Th1-driven autoimmune response.	[35]
PARP-1 deficient mice	Arthritis induced by anti-collagen antibodies	Reduced arthritis severity.; Reduced synovial inflammation and cartilage damage.; Reduced IL-1 and MCP-1 expression.	[36]
GPI6150	Adjuvant-induced arthritis	Reduced paw edema.; Reduced neutrophil infiltration.	[37]