Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease

Figure 1

Schematic representation of polymorphisms in the NLRP3 gene investigated in relation to inflammatory diseases. Exons of the NLRP3 gene are displayed as white boxes (not to scale). Upregulation of NLRP3 is indicated as (↑) beside the SNP rs number; polymorphisms with unknown biological function are not labeled. The lower panel represents the different domains of NLRP3: PYD, pyrin domain; NAD, NACHT associated domain; and LRR, leucine-rich repeat.