Proteasome Inhibitor Bortezomib Suppresses Nuclear Factor-Kappa B Activation and Ameliorates Eye Inflammation in Experimental Autoimmune Uveitis

Figure 2

The evaluation of protein expression of inflammatory mediators in retinas of EAU mice in Luminex analysis. Decreased expression of TNF-α (a), IL-1α (b), IL-1β (c), IL-17 (f), IL-12 (h), and MCP-1 (i) relative to the expression in the saline-treated group was noted in the high-dose bortezomib (Vel [H]) group but not in the low-dose bortezomib (Vel [L]) group except for TNF-α. In addition, there was no significant difference on the expression of IFN-γ (d), IL-4 (e), and IL-6 (g) in retinas between bortezomib and saline-treated mice. Data are expressed as the mean SD of three independent experiments (bar graph). , , and , via Student’s -test.

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