Proteasome Inhibitor Bortezomib Suppresses Nuclear Factor-Kappa B Activation and Ameliorates Eye Inflammation in Experimental Autoimmune Uveitis

Table 1

Effect of high-dose versus low-dose bortezomib (Velcade) on EAU^a.

Treatment	Incidence	Mean peak disease score
Saline	14/19
Vel (L)^b	10/17
Vel (H)^c	3/

Data are compiled from three experiments in which similar results were obtained.
^bLow-dose bortezomib 0.15 mg/kg ip treatment.
^cHigh-dose bortezomib 0.75 mg/kg ip treatment.
, via the Chi-square test, between saline and Vel (H) groups.
^#, via the Wilcoxon signed-rank test, between saline and Vel (H) groups.
⁺, via the Wilcoxon signed-rank test, between Vel (L) and Vel (H) groups.