The Combination of N-Acetyl Cysteine, Alpha-Lipoic Acid, and Bromelain Shows High Anti-Inflammatory Properties in Novel In Vivo and In Vitro Models of Endometriosis

Figure 1

NAC/LA/Br reduces the number and the dimension of cysts in a new in vivo model of EM. (a) Histochemical analysis of an endometriotic lesion in mice with Diff-Quick staining. Original Magnification 100x. (b) Immunohistochemical analysis of a cyst excised from the peritoneum of mice. Sections were stained with rabbit anti-vWF followed by a secondary antibody to rabbit IgG HRP conjugated and revealed with DAB. The inset showed the staining obtained with only secondary antibody. Original Magnification 100x. (c) Number of cysts counted in untreated mice () or treated with NAC 250 mg/kg/die, AL 125 mg/kg/die, and Br 12,5 mg/kg/die (). Mann-Whitney test . (d) Representative image of the different morphological appearance of cysts in treated or untreated SCID mice.

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