Bleomycin-Treated Chimeric Thy1-Deficient Mice with Thy1-Deficient Myofibroblasts and Thy-Positive Lymphocytes Resolve Inflammation without Affecting the Fibrotic Response
Table 3
Pathways involved in myofibroblast proliferation, differentiation, and interaction with the ECM and immune system that are affected by Thy1.
Category
Pathway
Gene name
Fold
Proliferation
Cell cycle
Anaphase promoting complex subunit 2
−1.19
Cyclin D2
−1.02
CDC23 (cell division cycle 23 yeast homology)
−1.13
Transformed mouse 3T3 cell double minute 2
−1.22
MAPK signaling pathway
RIKEN cDNA 1500003O03 gene
−1.03
Thymoma viral proto-oncogene 2
−1.12
Activating transcription factor 4
−1.1
Filamin C, gamma (actin binding protein 280)
−1.05
Protein phosphatase 1B, magnesium dependent, β isoform