Research Article

Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis

Table 1

Changes in parameters of expression of membrane-bound forms of IL-1β receptors types 1 and 2 on intact cells and monocytes in spontaneous and LPS-stimulated 24 h cultures and in serum levels of IL-1β cytokine and soluble receptors types 1 and 2 in healthy individuals and in patients with rheumatoid arthritis in the acute phase ( = 40) and after response to treatment ( = 24). The arrows denote the changes (↑ = increased, ↓ = decreased) compared with healthy individuals. % shows the changes in the percentage of positive cells; ρ is the change in density of receptor expression on cells. = a significant (p < 0.05) decrease in indicator in the group of patients who responded to therapy compared with this indicator in RA patients in the acute phase.

RA patients in acute phase RA patients after response to treatment
IL-1R1IL-1R2IL-1R1IL-1R2

IL-1R-expression in cell subsets
T cellsρρ↑ %
B cellsρρ↑ % and ↓ ρ↑ %
Monocytes↓ % and ↑ ρρ↓ % and ↑ ρρ
Monocytes in spontaneous PBMC culturesρρρρ
Monocytes in LPS-stimulated PBMC cultures↓ % and ↑ ρρ↓ % and ↑ ρρ

Serum content
IL-1β
raIL-1
Soluble receptor