Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data

Figure 4

Target molecules in lysosome pathway dysregulated in human sepsis. Lysosome is a cytoplasmic organelle containing enzymes that break down biological polymers. Organization of the lysosome is depicted as dense spherical vacuole containing a variety of acid hydrolases (close circle: proteases; open circle: galactosidase; open triangle: sulfatase) that are active at the acidic pH maintained within the lysosome. Furthermore, both the major (double rectangle boxes in grey) and minor (double rectangle boxes) lysosomal membrane proteins are involved. ATPase (H⁺ transporting) is displayed as open rectangle and “other lysosomal enzymes and activities” are displayed as close star.