Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data
Table 2
Whole blood transcriptional profiles identified top up- and downregulated pathways in human sepsis.
Upregulated pathways
Rank scores
Downregulated pathways
Rank scores
Lysosome
47
Ribosome
69
Regulation of actin cytoskeleton
46
Spliceosome
55
Pathways in cancer
45
Antigen processing and presentation
35
MAPK signaling pathway
34
Cell adhesion molecules
34
Fc gamma R-mediated phagocytosis
26
Intestinal immune network for IgA production
31
Chemokine signaling pathway
23
Graft-versus-host disease
28
Toll-like receptor signaling
17
Purine metabolism
21
Neurotrophin signaling pathway
16
Autoimmune thyroid disease
15
Insulin signaling pathway
16
Allograft rejection
14
Focal adhesion
14
T cell receptor signaling pathway
13
Leukocyte transendothelial migration
12
Cytokine-cytokine receptor interaction
9
Alzheimer’s disease
12
Primary immunodeficiency
8
Endocytosis
8
Natural killer cell mediated cytotoxicity
8
Olfactory transduction
8
Viral myocarditis
7
Cell cycle
7
Hematopoietic cell lineage
7
Renal cell carcinoma
6
RIG-I-like receptor signaling pathway
7
Oocyte meiosis
6
RNA degradation
6
Chronic myeloid leukemia
5
Jak-STAT signaling pathway
6
Complement and coagulation cascades
5
Type I diabetes melitus
4
Oxidative phosphorylation
4
Phosohatidylinositol signaling system
4
Fc epsilon RI signaling pathway
2
Inositol phosphate metabolism
1
Pathways were listed according to rank scores (from high to low). Rank scores were given to the top 10 up- or downregulated KEGG pathways in each study (with rank scores assigned from 1 to 10, 10 represented the most significant pathway) and a top KEGG pathway was defined if it had the highest combined rank scores and most appearances across all studies.
