Anti-Inflammatory and Antinociceptive Activities of Anthraquinone-2-Carboxylic Acid

Figure 2

Effect of AQCA on in vivo nociceptive symptoms. (a) Effect of AQCA on arachidonic acid-induced ear edema was evaluated in ICR mice that were treated orally with AQCA (0, 3, and 30 mg/kg) or indomethacin (5 mg/kg) for 7 days and with topical application of 2% arachidonic acid solution (25 μL/ear) to the left ear. The thickness of the edema was measured with a constant-pressure thickness gauge 1 h after treatment with arachidonic acid. The ear thickness of mice treated with the inducer alone was considered to be 100%. (b) Effect of AQCA on acetic acid-induced writhing was evaluated in ICR mice that were treated orally with AQCA (0, 3, 30, and 60 mg/kg) or indomethacin (10 mg/kg) for 3 days and intraperitoneally injected with 5% arachidonic acid solution. The number of writhings was recorded over 20 min and expressed as a percentage relative to the number of writhings in vehicle controls. compared with the control group.

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