Review Article
Epidermal Growth Factor and Intestinal Barrier Function
Table 1
The applications of EGF for animals on intestinal development.
| Animal | Dose | Significant results | Reference |
| Fetal rabbit | 300 µg/kg/d | EGF infusion significantly increased intrauterine growth retardation, fetal small intestinal villus height, and crypt cells | [35] | Early-weaned pigs | 1.5 mg/kg | Increased the mucosa IgA levels and crypt depth at jejunum on day 28 after weaning | [36] | Early-weaned mice | 50 µg/kg | Increased mean villous height and crypt depth and enhanced enterocyte proliferation | [37] | 1-day-old, large white-duroc cross breed piglets | 10 µg/kg/d | Stimulates proliferation of intestinal crypt epithelial cells and promotes recovery from atrophic enteritis in PEDV-infected piglets | [49] | Early-weaned pigs | 1.0 mg/kg diet | Failed to alter the small intestinal villus morphology, DNA, or protein content of gastrointestinal mucosa | [19] | Early-weaned pigs | 50 µg/kg BW/d | Greater jejunal and duodenal villus heights; greater intestinal length | [20] | Early-weaned pigs | 180 µg/d | Increased villous height in the duodenum, jejunum, and ileum | [21] | Early-weaned pigs | 115 µg/kg BW/d | Enhanced jejunal structure development, increased villi height, and decreased lamina propria width | [15] | Early-weaned pigs | 180 µg/d | Increased villus height and increased the intestinal structural integrity proteins expression | [22] | Early-weaned pigs | 60 µg/kg BW/d | Enhanced mean villous height, crypt depth, and villous height: crypt depth and stimulated proliferation of piglet enterocytes | [38] | Early-weaned rats | 50 μg/kg | Enhanced mean villous height, crypt depth, total protein, DNA, and RNA and stimulated enterocytes proliferation | [39] |
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