Mediators of Inflammation / 2016 / Article / Tab 2 / Review Article
Epidermal Growth Factor and Intestinal Barrier Function Table 2 The effects of EGF on EGF-mediated protection of tight junctions.
Cell lines Inducer TJ associated proteins Involved pathways Reference Caco-2 Hydrogen peroxide Increased in tubulin polymerization PKC-β 1 [50 ] Caco-2 Hydrogen peroxide Increased in tubulin polymerization and decreased in monomeric tubulin PKC- [51 ] Caco-2 Hydrogen peroxide Increased F-actin-to-G-actin ratio PKC-β 1 ↑; NF-κ B ↓2 [52 ] Caco-2 Acetaldehyde Occludin ↑; ZO-1 ↑1 Inhibited tyrosine phosphorylation [53 ] Caco-2 Hydrogen peroxide F-actin ↑; G-actin ↓ PLC-γ ↑; NF-κ B ↓ [40 ] Caco-2 Hydrogen peroxide Occludin ↑; ZO-1 ↑ ERK-MAPK [23 ] Caco-2 Acetaldehyde Occludin ↑; ZO-1 ↑ Not mentioned [54 ] Caco-2 Acetaldehyde Occludin ↑; ZO-1 ↑ PLC-γ /PKC [55 ] Caco-2 Acetaldehyde Occludin ↑; ZO-1 ↑ ERK1/2-MAPK [24 ] NRC-1 cells3 Hydrogen peroxide ZO-1 ↑; claudin-3 ↑ PLC-γ /PKC [56 ] MCAS4 None Claudin-3 ↓ MEK/ERK or PI3K/Akt [57 ] HUOA5 Claudin-4 ↓ MDCK6 None Claudin-4 ↑ MEK/ERK [58 ] MDCK None Claudin-2 ↓; claudin-4 ↑ Src and STAT3 [25 ]
Symbols ↑ and ↓ indicate increases and decreases in the protein or mRNA expression, respectively. 2 Symbols ↑ and ↓ stand for activation and inhibition, respectively. 3 Cholangiocytes. 4 Mucinous cystadenocarcinoma. 5 Serous cystadenocarcinoma. 6 Darby canine kidney cells.