Administration of Myelin Basic Protein Peptides Encapsulated in Mannosylated Liposomes Normalizes Level of Serum TNF-α and IL-2 and Chemoattractants CCL2 and CCL4 in Multiple Sclerosis Patients

Figure 1

Serum levels of cytokines (pg/mL) in the treatment group at the time of the screening (−2 weeks), 7, 10, and 18 weeks. The interquartile range is shown by boxes. The median in each group is shown by the bold line. Bars represent 95% confidence interval. Statistically significant differences with their respective values are indicated. The green line represents cytokine levels in healthy individuals. The green-colored zone corresponds to the interquartile range in healthy individuals according to the previously reported data (see Section 2 for details). In the upper line, cytokines that had a statistically significant improvement are depicted.