Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer

Figure 1

Model of the IL-2R signalling pathway. Zhou et al. [8] propose the model as follows: (a) the first molecule activated is JAK3 and the next molecule in the pathway is JAK1; Syk functions as a downstream element of the JAKs in IL-2 signalling. JAK3 may regulate Syk and STAT activity indirectly via JAK1. Our model proposed for cervical cancer cells is shown in (b). The crossed arrows represent the steps that are not performed in cervical cancer cells but appear in the normal cell model. The rectangle shows a step that is not found in the normal cell model.

(a)

(b)