Pleiotropic Effects of IL-2 on Cancer: Its Role in Cervical Cancer

Figure 2

Concentration of IL-2 and activation of tumour-infiltrating lymphocytes. Low concentrations of IL-2 may promote the regulatory microenvironment and tumour growth. High concentrations of IL-2 activate immune system cells, such as CD8⁺, CD4⁺, and γδ T cells and NK cells; these cells produce proinflammatory cytokines, such as IFN-γ, and eliminate tumour cells.