Increased Kappa/Lambda Hybrid Antibody in Serum Is a Novel Biomarker Related to Disease Activity and Inflammation in Rheumatoid Arthritis

Figure 3

The relationship between serum levels of κ/λ hybrid antibody and RA-related clinical parameters. (a) Levels of κ/λ hybrid antibody in the serum of RA patients correlated with RF (, ). (b) Levels of κ/λ hybrid antibody were significantly higher in ACPA(+) than ACPA(−) group with ; the differences of κ/λ hybrid antibody levels between groups were assessed using the Mann-Whitney test; solid line was labeled at mean with SEM, . (c, d) Levels of κ/λ hybrid antibody in the serum of RA patients correlated with IFN-γ (, ) and D-dimer (, ). Concentrations of κ/λ hybrid antibody are presented in arbitrary units (AU/mL). Symbols represent individual subjects. Correlations were determined by Spearman’s rank correlation coefficients with 95% confidence interval.

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