Circulating Memory T Follicular Helper Cells in Patients with Neuromyelitis Optica/Neuromyelitis Optica Spectrum Disorders

Figure 6

Correlation analysis of different subsets of circulating memory Tfh cells with the values of clinical measures in NMO/NMOSD patients. ((a)-(b)) The percentages of CCR7⁻ and CCR7⁻ICOS⁺ memory Tfh cells were positively associated with the ARR in NMO/NMOSD patients. ((c)-(d)) The percentages of CCR7⁻ and CCR7⁻ICOS⁺ memory Tfh cells were positively associated with the levels of plasma IL-21. ((e)-(f)) The percentages of CCR7⁻ and CCR7⁻ICOS⁺ memory Tfh cells were positively associated with the levels of plasma AQP4 Ab in AQP4 Ab-seropositive patients. ((g)-(h)) The percentages of CCR7⁺ and CCR7⁺ICOS⁺ memory Tfh cells were positively correlated with CSF WBC counts. ((i)-(j)) The percentages of CCR7⁺ and CCR7⁺ICOS⁺ memory Tfh cells were positively correlated with the levels of CSF proteins. ((k)-(l)) The percentages of CCR7⁺ and CCR7⁺ICOS⁺ memory Tfh cells were positively correlated with the levels of CSF IL-21.

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