The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma

Figure 2

OGG1-BER induced gene expression associated to airway mast cell degranulation. Mouse lungs received a single challenge (SC) or multiple challenges (MC) with 8-oxoG. Lungs were collected at 30 and 60 min after challenge and analyzed at whole-transcriptome level by RNA-Seq. (a) Hierarchically clustered heat map was generated using GENE-E online software (Broad Institute, http://www.broadinstitute.org/) considering transcript levels (fold-change). Red represents upregulation and blue represents downregulation. (b) Enrichment interaction network of the known and predicted interactions among the set associated with mast cell degranulation and OGG1. Peripheral nodes represent genes with a direct interaction with OGG1. The modified network was generated with GeneMania online database (http://www.genemania.org/).

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