Review Article

The Potential Role of 8-Oxoguanine DNA Glycosylase-Driven DNA Base Excision Repair in Exercise-Induced Asthma

Table 1

OGG1-BER induced expression of genes involved in mast cell degranulation.

SymbolNameGenBank/RefSeq IDSC (fold)MC (fold)

Itga6Integrin alpha 6NM_008397−1.2829.12
Foxf1Forkhead box F1NM_0104261.6318.98
Plcg1Phospholipase C, gamma 1NM_0212801.1517.11
AlbAlbuminNM_009654−1.7415.28
Pla2g3Phospholipase A2, group IIINM_172791−7.069.71
ArAndrogen receptorNM_013476−2.169.58
Cxcl9Chemokine (C-X-C motif) ligand 9NM_008599−1.519.09
Ms4a2Membrane-spanning 4-domains, subfamily A, member 2NM_0135161.338.38
TnfTumor necrosis factorNM_01369316.657.13
NfkbiaNFKLP gene enhancer in B cells inhibitor, alphaNM_0109074.734.41
Grap2GRB2-related adaptor protein 2NM_0108151.183.53
ItkInterleukin 2 inducible T cell kinaseNM_0105831.383.34
Traf6Tumor necrosis factor receptor-associated factor 6NM_0094241.092.94
Ccl11Chemokine (C-C motif) ligand 11NM_011330−1.712.93
Pdpk13-phosphoinositide dependent protein kinase 1NM_011062−1.222.73
Pik3cgPhosphoinositide-3-kinase, catalytic, gamma polypeptideNM_0202721.022.67
Rasgrp1RAS guanyl releasing protein 1NM_0112461.212.62
Il1r1Interleukin 1 receptor, type INM_0083621.242.55
Pld1Phospholipase D1NM_0088751.022.49
Hmox1Heme oxygenase 1NM_010442−1.432.46
Pik3cbPhosphatidylinositol 3-kinase, catalytic, beta polypeptideNM_029094−1.022.34
FerFer (fms/fps related) protein kinaseNM_008000−1.602.33
Ubash3bUbiquitin associated and SH3 domain containing, BNM_1768601.122.25
KitKit oncogeneNM_0210991.392.20
Gp1baGlycoprotein 1b, alpha polypeptideNM_0103261.282.16
Hrh1Histamine receptor H1NM_008285−2.852.15
FynFyn proto-oncogeneNM_0080541.212.14
Plcg2Phospholipase C, gamma 2NM_1722851.082.12
ElaneElastase, neutrophil expressedNM_015779−1.432.09
Gab2Growth factor receptor bound protein 2-associated protein 2NM_0102481.152.09

SC, single 8-oxoG challenge; MC, multiple 8-oxoG challenge; NFKLP, nuclear factor of kappa light polypeptide; GRB2, growth factor receptor-bound protein 2. RAS, rat sarcoma. The table shows the top ranked genes (MC, 60 min) by expression level (≥2-fold).