e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease

Figure 3

(a) Fluorescence immunostaining of e-cadherin and tyrosine hydroxylase (TH) by using specific antibodies in the substantia nigra area of control and experimental midbrain. 40x magnification. (b) The immunofluorescence area density was quantified by densitometry scanning and analysis with Scion Image; the data represent the mean ± SD of three separated experiments. versus control sample. The arrows indicate the distribution of e-cadherin and TH fluorescence; e-cadherin is randomly distributed in control sample and has specific localization around the soma in experimental sample. TH florescence is evident around the neurons and along the neurofilaments in control sample whereas it is distributed uniformly in the tissue surrounding the cells.

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