Interleukin-27 as a Novel Biomarker for Early Cardiopulmonary Failure in Enterovirus 71-Infected Children with Central Nervous System Involvement

Figure 1

Serum IL-27 levels in EV71-infected patients. Serum IL-27 levels in 127 EV71-infected HFMD patients (including 55 clinical stage II cases, 42 stage III cases, and 30 stage IV cases) and 95 healthy controls were detected by ELISA. Values are expressed as means ± SEM. (a) Serum IL-27 levels were significantly higher in EV71-infected HFMD patients than in healthy controls (). (b) Serum IL-27 levels in clinical stage III EV71-infected HFMD patients were higher than clinical stage II and clinical stage IV EV71-infected patients (). (c) Serum IL-27 levels in followed-up stage IV patients, the day of admission (TP0), the day the disease improved (TP1), and the day the disease recovered (TP2). ; ; .

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