Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis

Figure 1

Adrenal glands are important to control clinical outcome in experimental colitis. C57BL/6 mice were adrenalectomized and exposed to dextran sulfate sodium (DSS) 3%. On day 6 mice were euthanized to obtain samples of serum: (a) plasma corticosterone levels; (b) overall clinical score of the disease; (c) postmortem score; (d) serum IL-6 levels; (e) serum lipopolysaccharide (LPS) levels. DSS: C57BL/6 mice exposed to DSS; ADX + DSS: C57BL/6 adrenalectomized mice exposed to DSS. The dashed lines correspond to the control group of C57BL/6 mice not exposed to DSS. Continuous line in (a) corresponds to adrenalectomized mice without colitis. EU/mL = endotoxin units/mL. These results are representative of 3 independent experiments with 5 mice/group. .

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