Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis

Figure 4

Adrenal-derived mediators altered the accumulation of lymphocytes in the intestine.C57BL/6 mice were adrenalectomized and exposed to dextran sulfate sodium (DSS) 3%. The colon was collected on the 6th day of colitis for phenotypic characterization of leukocytes from LP (lamina propria) (a) and IEL (intraepithelial cells) (b). After acquisition, samples were analyzed by FlowJo software. DSS: C57BL/6 mice exposed to DSS; ADX + DSS: C57BL/6 adrenalectomized mice exposed to DSS. The dotted lines correspond to the control group of C57BL/6 mice without colitis. Results are representative of two independent experiments, with 5 mice/group. .

(a)

(b)