Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Figure 5

The expression of MMP-3 and MMP-9 mRNA in Caco-2 cells and human leucocytes. After 24 h stimulation with 5-HT for 24 h, MMP-3 mRNA expression in Caco-2 cells was significantly increased at the concentration of 5 and 10 μM (a). The expression of MMP-9 mRNA was up to 6-fold increase compared to the leucocytes without 5-TH stimulation (b). The data represent 4 experiments. versus cells without treatment with 5-HT.

(a)

(b)