Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon

Table 2

The changes of body weight colon length and histopathology of mice in each group.

Group	Control	1 mg 5-HT	2 mg 5-HT	1% DSS	1% DSS + 1 mg 5-HT	2.5% DSS
n	8	9	9	14	12	7
Change of BW (%)	2.1 ± 2.4	1.8 ± 1.8	0.9 ± 3.3	−5.9 ± 4.2	−19.0 ± 5.9	−21.6 ± 5.9
Colon length (cm)	7.8 ± 0.5	7.6 ± 0.3	7.4 ± 0.4	6.4 ± 0.6	5.2 ± 0.7	4.9 ± 0.5
Colon H&E staining scores	0.1 ± 0.1	0.3 ± 0.1	0.4 ± 0.2	6.3 ± 0.9	10.7 ± 2.5	11.6 ± 1.9

Change of BW presents the change of mouse body weight at day 6.
P < 0.05 versus control mice.