Pathogen-Associated Molecular Patterns Induced Crosstalk between Dendritic Cells, T Helper Cells, and Natural Killer Helper Cells Can Improve Dendritic Cell Vaccination

Figure 2

DC-derived IL-12p70 production upon single and multiple PRR triggering. (a) iDC were matured in the presence of IFN-γ and different PRR triggers as indicated on -axis. Cytokine production was determined in the culture supernatant after 48 h of maturation. Data are represented as mean + SEM and representative of at least 6 independent experiments. Kruskal-Wallis test significance as compared to DC matured with IFN-γ. , , and . (b) Synergy of FMKp/IFN-γ (FI) maturation with poly(I:C) and CL075 as measured by their IL-12p70 production.

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