Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

Figure 2

Recruitment pattern of myeloid cells in tumor progression and metastasis. Stages in tumor progression and metastasis including initiation, proliferation and tumor site inflammation, invasion, intravasation, circulation in blood stream, extravasation, and colonization are shown with associated myeloid cells, platelets, and cytokines. The contribution of TAM and TAN at early stage of distant colonization sites is not clear. Green: cytokines/chemokines in recruitment or suppression of immune cells, black: metastasis associated proteins, red arrow: movement of myeloid cells, EMT: epithelial mesenchymal transition, and CTSB: cysteine protease cathepsin B based on [105].