Epigenetic Control of Macrophage Polarisation and Soluble Mediator Gene Expression during Inflammation

Table 4

HDACs involved in macrophage polarisation.

Name	Class	Function	References
—	Classes I and II	Pattern recognition receptors, activation markers, cytokines, chemokines, secretion of reactive oxygen species, and NO induction	[30, 55–57]
—	Classes I and II	MIF induction	[58]
—	Classes I and II	Cd16 induction, Cd206, TNF-α, and NO repression	[59]
—	Classes I and II	PU.1 induction	[60, 61]
—	Classes I and II	Arg1 induction	[62]
—	Class I	IL-12, TNF-α secretion, IL-10 repression, and CD40/80 induction	[63]
HDAC1	Class I	IFNA and IL6 repression	[54]
HDAC1	Class I	Cox2, Pai1 inhibition, and Edn1 induction	[64]
HDAC2	Class I	Ciita inhibition	[65]
HDAC2	Class I	M2-IL4 activation status	[33]
HDAC2	Class I	Il6 repression	[52]
HDAC3	Class I	IFN-β secretion	[66]
HDAC3	Class I	TGF-β suppression	[67]
HDAC3	Class I	IL-6, NO secretion	[30]
HDAC6	Class IIb	Edn1 and Il12b induction	[64]
HDAC7	Class IIa	Il12b, Il6, and Edn1 induction	[68]
HDAC9	Class IIa	PPAR-γ, ABCA1, and ABCG1 repression	[69]
HDAC9	Class IIa	M2-IL4 activation status	[33]
SIRT1	Class III	Tnf, Il6, Nos2, and Mcp1 represion	[70]
SIRT1	Class III	TNF-α, IL-1β, IL-6, IL-12, and MCP-1 inhibition	[71–73]
SIRT1	Class III	PGE2 inhibition	[74]
SIRT1	Class III	M2-IL4 activation status	[33]
SIRT2	Class III	Tnf, Il6, Mcp1 repression, Il4r, and Il10 induction	[75]
SIRT2	Class III	Tnf, Il1β, Il6, Cox2, Nos2, and reactive oxygen species inhibition	[76]
SIRT2	Class III	iNOS, TNF-α, IL-6, CD40/80, IL-10, and reactive oxygen species inhibition	[77]
SIRT6	Class III	Il1β repression	[72]
HDAC11	Class IV	Il10 downregulation	[78, 79]
HDAC11	Class IV	IL-1β repression	[80]