Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice

Figure 5

Gene expression of inflammatory mediators. Gene expression of macrophage-related chemokines (a) CCL2 and (b) CCL4 and (c) neutrophil-related CCL3 as well as cytokines (d) macrophage colony-stimulating factor (M-CSF), (e) TNF-α, (f) IL-10, and (g) osteopontin (OPN)-1. = 8–10/group; RT-qPCR using Taqman, mRNA expression is related to shams and GAPDH using comparative ΔΔCt-method; indicates P ≤ 0.05 between the genotypes; # indicates P ≤ 0.05 versus respective sham.

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