Epithelial Anion Transport as Modulator of Chemokine Signaling

Table 1

Anion transport activity changes and proinflammatory chemokine and cytokine secretion in different diseases.

	Disease	Transporter/channel function	Augmented chemokines/cytokines
Airway system	CF	CFTR	CXCL8, CXCL1, CXCL2, CCL3, CCL18, IL-1β, IL-6, IL-33, TNFα, GM-CSF, G-CSF, HMGB1
	COPD	CFTR	CXCL8, CXCL1, CCL2, CCL8, CCL18, IL-6
	Asthma	CFTR; SLC26A4; TMEM16A; SLC26A9	CXCL8, IL-1β, IL-6, IL-13, TGF-β1, GM-CSF
Gastrointestinal system	Pancreatitis	CFTR; CFTR; SLC26A3/A6	CXCL8, IL-1, IL-6, TNF-α
	Cholestatic liver diseases	CFTR; CFTR; AE2	CXCL8, CXCL1, CXCL5, CXCL6, CXCL10, CCL2, CCL3, CCL4, CCL5,

CFTR: carriers of CFTR mutations have an increased risk to develop disease.