Epithelial Anion Transport as Modulator of Chemokine Signaling

Table 2

Clinical trials for CF therapy indirectly targeting the lack of CFTR-mediated anion transport in the lung by ion-replacement or activation of alternative anion channels.

Therapeutic approach	Compound	Type of administration	Result	References
Mucus rehydration	Hypertonic saline	Nebulized	Modest increase in lung function	[241, 242]
Antioxidant treatment	GSH	Nebulized	Small or no effect on lung function	[288, 289, 312]
	N-acetylcysteine	Oral	Modest increase in lung function	[291, 294]
TMEM16A function	Denufosol	Inhaled	Small or no effect on lung function	[305, 313]