Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis

Figure 5

Analysis of innate immune response after pneumococcal meningitis in different brain regions. 30 h after subarachnoid infection with Streptococcus pneumoniae, mRNA expression of TNF-α (a and e), IL-6 (b and f), IL-1β (c and g), and IL-1RA (d and h) was determined in the hippocampal formation and cortex of TNFR1-, IL-6-, or TNFR1-IL-6-KO and WT mice by real-time RT-PCR. Data were assessed from five independent experiments in duplicate. An asterisk indicates a significant difference between infected WT and infected TNFR1-, IL-6-, or TNFR1-IL-6-KO mice as determined by ANOVA followed by Bonferroni test (; ; ).

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