Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF-κB and CCAAT/Enhancer-Binding Protein δ Pathways

Figure 11

During LPS stimulation, both NF-κB and p38 MAPK/ERK1/2—C/EBPδ pathways are activated, which contribute to production of proinflammatory mediators and acute lung injury. However, Bigelovii A, as a new discovered natural product from the dried herbs of Salicornia bigelovii Torr., can disrupt LPS induction of both signaling pathways, leading to attenuation of inflammatory responses.