Bigelovii A Protects against Lipopolysaccharide-Induced Acute Lung Injury by Blocking NF-κB and CCAAT/Enhancer-Binding Protein δ Pathways

Figure 3

Effect of Bigelovii A on LPS-induced production of inflammatory mediators in BAL fluids. ALI was induced by intratracheal administration of LPS. 18 h or 60 h later, BAL fluids were extracted and generation of IL-6 (a and e), MCP-1 (b and f), MIP-1α (c and g), and MIP-2 (d and h) was measured. Results are reflected by means ± SEM [ for Vehicle plus PBS group (negative control) or Bigelovii A+PBS group, for LPS+Vehicle group (positive control), and for LPS+Bigelovii A group]. and indicated statistically significant difference, and 0.001, respectively.

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