Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation

Figure 2

Effect of TRAF5 deficiency on the histopathology and MPO activities of colon tissues. Histological evaluation of DSS-induced colitis was performed by microscopy and H&E staining. Colon sections from TRAF5 KO and WT mice were scored in a blinded fashion, as described in Section 2. (a) Representative cross sections of the distal colon. The magnifications of the images are 100-fold and 400-fold. (b) Quantitative results of the histological analysis ( per group). (c) MPO activities in the colons were determined as described in Section 2 ( per group). The data are presented as the mean ± SD. versus the DSS-treated WT group and versus the DSS-treated WT group.

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