Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation

Figure 4

Deletion of TRAF5 increases the protein expressions of the cytokines IFN-γ, IL-4, and IL-17a in the colons of mice induced by DSS. (a) The production of IFN-γ, IL-4, and IL-17a in the colons of DSS-induced mice or control mice was examined by ELISA ( per group). (b) Representative immunofluorescence staining for IFN-γ, IL-4, and IL-17a in the colons of TRAF5 KO and WT mice (magnification 400x). (c) Quantification of positive cells ( per group). The data are representative of 3 independent experiments (mean ± SD). versus the DSS-treated WT group; versus the DSS-treated WT group.

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