PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells

Figure 5

PGC-1α upregulation is required for optimal secretion of IFN-γ production in human NK cells. Quantification of IFN-γ was performed by ELISA. Purified human NK cells were transfected with siRNA specific for PGC-1α or negative control and then treated with 50 (control) or 2000 (activated) IU/mL of IL-2 for 72 h. Results show the mean of 5 independent experiments ± SE ().