Interleukin-17: Potential Target for Chronic Wounds

Figure 1

Skin wounding induces the release of IL-17A, IL-17F, and IL-17C from keratinocytes and leukocytes. These ligands bind to their respective heterodimeric receptors (IL-17A and IL-17F at IL-17RA/RC; IL-17C at IL-17RA/RE) on keratinocytes and leukocytes to release antimicrobial peptides, chemokines, and cytokines—contributing to a self-perpetuating cycle of inflammation. TGF-β: transforming growth factor-β; IL: interleukin; TNF-α: tumor necrosis factor-α; ILC3: Type 3 innate lymphoid cells; NKT: natural killer T; T_H17: T-helper 17; RA: receptor A subunit; RC: receptor C subunit; RE: receptor E subunit; MAPK: mitogen-activated protein kinase; NF-κB: nuclear factor-kB.