Phenolic Compounds Isolated from Calea uniflora Less. Promote Anti-Inflammatory and Antioxidant Effects in Mice Neutrophils (Ex Vivo) and in Mice Pleurisy Model (In Vivo)

Table 2

Effects of noreugenin (NRG) and α-hydroxy-butein (AH-BU) on antioxidant enzyme activities and TBARS concentration in carrageenan-induced inflammation in the mouse model of pleurisy.

Groups/dose (mg/kg)	CAT (mmol/min/mL) (% of inhibition)	SOD (USOD/mL) (% of inhibition)	GST (μmol/min/mL) (% of inhibition)	TBARS (mmol/mL) (% of inhibition)
Sal^a
Cg^a
Dex (0.5)^b
NRG (5)^b
AH-BU (2.5)^b

CAT: catalase; SOD: superoxide dismutase; GST: glutathione S-transferase; TBARS: thiobarbituric acid reactive substances. Noreugenin (NRG: 5 mg/kg) and α-hydroxy-butein (AH-BU: 2.5 mg/kg) administered 0.5 h before pleurisy induction by carrageenan (1%). Sal = animals treated with sterile saline solution (NaCl 0.9%) only. Cg = animals treated with carrageenan (1%) only. Dex = animals pretreated with dexamethasone (0.5 mg/kg). ^aAdministered by intrapleural injection (i.pl.). ^bAdministered by intraperitoneal route (i.p.). Each group represents the of 5 animals. and compared to the positive control group (Cg); ANOVA/Newman–Keuls test.