Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells

Figure 4

MBL attenuated expression of NK cell activation markers. NK cells were stimulated with 100 U/ml recombinant IL-2 in the presence or absence of 20 μg/ml MBL for 24 hours or 72 h. Representative histogram and statistical analysis showed the expression profiles of indicated receptors in NK cells treated with (thick lines) or without MBL (thin lines). The shaded curves describe cells stained with corresponding isotype control. MFI = geometric mean. ; ; , compared to the group with IL-2 alone. Data are presented as (horizontal lines) ().