Over the last two decades, the role of C-reactive protein (CRP), the prototype human acute phase protein, in cardiovascular disease has been extensively studied and discussed. The underlying reasons are briefly summarized as follows. First, arteriosclerosis is an inflammatory disease and CRP is a mediator of inflammation. Second, CRP has been identified as a cardiovascular risk marker. Third, CRP may be causally involved in atherogenesis and its sequelae. Lastly, CRP may be a target for cardiovascular drug development.

Controversial data have been accumulated that either support or contradict these scientific concepts. We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the role of C-reactive protein in cardiovascular disease. Potential topics include, but are not limited to:

• C-reactive protein: biological function and role in acute phase response
• C-reactive protein as a cardiovascular risk marker
• C -reactive protein in the arterial wall
• Animal models of C-reactive protein and cardiovascular disease
• Inhibiting C-reactive protein for the treatment of cardiovascular disease

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