| Parameters | Number of studies | Refs |
| Questionnaires | | | GERD symptoms score | 23 | [3–6, 8, 11, 15, 16, 18, 20, 24, 25, 27, 29, 32–37, 39, 40] | Gastroesophageal Reflux Disease Activity Index (GRACY) | | Digestive Health Survey Instrument | | Gastrointestinal Symptoms Rating Scale (GSRS) | | Jamieson Score | | Gastrointestinal Quality of Life Index (GIQLI) | 3 | [25, 27, 33] | Psychological General Well-Being Index (PGWBI) | 2 | [23, 39] | Short-form 36 (SF 36) | 2 | [6, 22] | Health-Related Quality of Life (HRQL) | 1 | [34] | Well-Being Score (WBS) | 1 | [2] | Visual Analogue Score (VAS) | 1 | [11] | Patients satisfaction | 16 | [2–6, 11, 18, 20, 24, 29, 32–35, 38] | VA clinical data base (outpatients clinics) | 1 | [26] | Clinical assessment at follow-up visit | 7 | [4, 11, 19, 22, 31, 38, 39] | Objective esophageal tests | | | Endoscopy | 8 | [3, 6, 14, 15, 22, 23, 30, 31] | Esophageal manometry | 7 | [8, 11, 15, 17, 19, 20, 38] | 24-h Esophageal pH-metry | 18 | [6, 8, 11, 14–20, 27, 32–37, 40] |
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